A random sample of elderly women over age 70, members of Maccabi Healthcare Services in the greater Jerusalem area, will be invited to participate.
All participants will be interviewed using a structured questionnaire focusing on demographics, medical status and osteoporosis risk factors including previous fractures, age, smoking, medications etc and their frailty status determined using two sets of criteria developed by Fried (1997) and Saliba (1998).
Osteoporosis status will be determined using densitometric techniques.
Prevalence of frailty will be determined in osteoporotic vs non osteoporotic elders controlling for known risk factors.
Non frail elders at baseline will be followed for two years at 6 month intervals to determine the incidence of frailty in osteoporotic vs non osteoporotics. Multiple regression techniques will be used to explore osteoporosis as a risk factor for frailty.